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Some Laryngopharyngeal Reflux Resists PPI Treatment

by Jill U. Adams • June 1, 2013

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Resolving the problem of how to treat LPR is not easy, and the philosophy on appropriate approaches will probably develop over the next few years. However, without good evidence-based data, finding clear answers will likely take longer than that.

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Explore This Issue
June 2013

Controversies Surrounding the Management of Patients with Reflux Disease

An additive effect

  1. Whether there is a different pathophysiology of abnormal acid and pepsin exposure in patients with LPR versus GERD.
  2. Uncertainty of what constitutes abnormal pharyngeal acid exposure.
  3. The current practice of twice-daily PPI therapy in LPR is neither FDA approved nor based on controlled studies.
  4. The role of diagnostic testing and the continued role of acid/peptic reflux in those who remain symptomatic despite aggressive dose and duration of acid suppression.

Source: Altman KW, et al. Laryngoscope. 2011;121:717-723.

Pages: 1 2 3 4 5 | Single Page

Filed Under: Features, Laryngology, Practice Focus Tagged With: Laryngopharyngeal reflux, LPR, PPI, proton pump inhibitorIssue: June 2013

You Might Also Like:

  • Laryngopharyngeal Reflux Gaining Recognition as Distinct Disorder, Paving the Way for Research and Treatment
  • Laryngologists v. Non-Laryngologist Treatment of Laryngopharyngeal Reflux
  • Experts Delve into Treatment Options for Laryngopharyngeal Reflux
  • High BMI a Significant Indicator of PPI Weaning Failure

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