Thyroglossal Duct Cyst Cancer Diagnosis Is a Heterogeneous Group

What are the best practices for thyroglossal duct cyst (TGDC) carcinoma management, especially that of the orthotopic thyroid gland?

Background: Although TGDC is common, primary carcinoma of the thyroglossal duct cyst (TGDC cancer) is rare, and is most typically papillary thyroid cancer (PTC). Currently, there is no consensus on optimal TGDC cancer management. Controversy mostly centers on the role of thyroidectomy, as well as lymph node dissection, postoperative thyroid suppression, and radioiodine treatment. It is often difficult to distinguish true TGDC cancer from other similar but discrete diagnoses, including pyramidal lobe PTC and Delphian node (i.e. prelaryngeal lymph node) PTC metastasis.

Study design: Retrospective review of 28 TGDC carcinoma (hospital-recorded diagnosis) patients.

Setting: Massachusetts Eye and Ear Infirmary and the Massachusetts General Hospital, Boston.

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