Harris P. Mosher Award
Giovana R. Thomas, MD, associate professor of otolaryngology at the University of Miami in Florida, was awarded the Mosher Award in recognition of her thesis in clinical research, “Human Papillomavirus (HPV) Induced Oropharyngeal Cancer in Hispanics in the U.S.: Differences in Clinical Presentation and Survival Outcomes.”
Explore this issue:July 2016
Dr. Thomas’ study is the first to describe the clinical details of Hispanic patients with HPV-induced oropharyngeal squamous cell carcinoma (OPSCC).
The incidence of HPV-induced OPSCC is increasing at an epidemic rate. Specifically, in the years 1988-2004, incidence of the disease increased by 225%. Likewise, research on the subject has increased, leading to a greater understanding of what Dr. Thomas described as a new and peculiar disease. In general, patients with HPV-induced OPSCC are middle-aged Caucasian men who are, more often than not, professionals with a history of multiple sexual partners. Thankfully, HPV-related OPSCC carries a favorable survival rate.
Most research on HPV-induced OPSCC, however, has focused on non-Hispanic whites, overlooking the Hispanic population, which is already the nation’s largest minority group, with 42 million individuals in 2005. Moreover, the Hispanic population is expected to triple in size by the year 2050. Dr. Thomas described the need to offer this growing population the best possible care. In order to help achieve this goal, she and her colleagues sought to determine disparities in survival outcome and clinical presentation between Hispanic and non-Hispanic whites. As physicians at the University of Miami Hospital, they took advantage of the fact that Miami has a very large Hispanic population, using the Hospital Tumor Registry Database to identify patients with OPSCC who presented between 2008 and 2014. The researchers identified 237 patients with OPSCC with well-documented HPV and/or p16 positive status. Of these, 167 were non-Hispanic whites and 70 were Hispanic. The demographics of the two groups were otherwise similar.
The patients had a mean age of 59 years. The majority of patients (84%) presented in advanced stages, and the majority (66%) had past or current history of alcohol use. The overall death rate in the study was 10%, and Dr. Thomas and colleagues found no significant difference between the Kaplan-Meier survival curves of non-Hispanic whites and Hispanics. Age was the only factor that had a significant effect on outcome, and this effect was similar in both groups.
Dr. Thomas did, however, identify some statistically significant differences between the groups in their presentation of disease. Specifically, 70% of Hispanic patients presented with primary disease, compared to 56% of non-Hispanic whites. Additionally, women represented a statistically significant larger proportion of HPV-positive Hispanic patients (26%) as compared with non-Hispanic whites (9%). Thus, the differences between the two groups were in the increased representation of women in the Hispanic group and the increased likelihood of primary disease in the tonsil region in the Hispanic group.
Edmund Prince Fowler Award
Paul Hong, MD, associate professor in the division of otolaryngology–head and neck surgery at Dalhousie University in Halifax, Nova Scotia, was awarded the inaugural Maureen Hannley Award for his thesis, “Parental Decision Making in Pediatric Otoplasty: The Role of Shared Decision Making in Parental Decisional Conflict and Decisional Regret.”