Antibiotics Show Limited Effectiveness in Eosinophilic CRS-Associated Inflammation

Are antibiotics an appropriate maximal medical therapy for the CRS subtype eosinophilic chronic rhinosinusitis (eCRS)?

Bottom line
The use of antibiotics without independent anti-inflammatory properties has limited efficacy in patients with eCRS.

Background: Advances in our understanding of the immunological processes underpinning CRS suggest that different subtypes exist. One subtype, eCRS, comprises T-helper cell type 2 (Th2) inflammation and local eosinophilic tissue infiltration, but its etiology remains elusive. Most clinicians continue to prescribe antimicrobial therapy that lacks any secondary anti-inflammatory properties for all patients with any CRS form.

Study design: Prospective individual cohort study of 39 patients presenting with CRS.

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