According to Drs. Pitman and Rubin, the list of other possible causes could include:
- Esophageal problems;
- Thyroid issues, such as thyroiditis and goiter;
- Muscle strain and muscle tension dysphonia from overuse of voice or tightness of muscles from speaking;
- Cervical spine osteophytes;
- Lingual tonsil hypertrophy;
- Medications, such as sprays that relax the throat; and
- Isolated cases in which tumors or malignancy cause a globus sensation.
Globus has been referred to as globus hystericus, although the term is out of use today. Although there is no connection to women’s health issues, as the term might suggest, there can be a connection between globus and anxiety. “Anxiety and globus is really a ‘chicken and egg’ scenario,” said Dr. Rubin. “It can be difficult to tell which was first to show up. Also, it is known that anxiety may make a globus sensation worse.”
Globus has been recognized as a symptom of depression and other psychological disorders. In a 2009 study, for example, globus was linked with depression and somatization disorder among a wide range of psychopathology in men (Psychosom Med. 2009;71:1026-1031).