“When you look at facial plastics, our nemesis is scar formation,” said Lamont R. Jones, MD, vice chair of the department of otolaryngology–head and neck surgery at Henry Ford Hospital in Detroit. “What is exciting about studying keloids is that if we understand what’s going on in keloids, we can exploit that knowledge for other uses in facial plastics.”
Because keloids are most commonly seen in people of African, Hispanic, and Asian descent, researchers have long suspected a genetic component to keloid formation. The observation that more than half of all patients with keloids report a family history of keloid scarring has strengthened that suspicion (Mol Med. 2011;17:113-125).
By 2008, researchers had identified at least one autosomal dominant inheritance pattern of keloids and some genes (most notably HLA-DRB1*15 and DQB1*0503) associated with an increased risk of keloid scarring (Mol Med. 2011;17:113-125). But keloids have also been associated with immune response and blood type, leading researchers to believe that keloid formation is much more complex than the presence, absence, or mutation of any one gene.| ← Previous | | | Next → | Single Page