How do nasal sprays and irrigations compare in delivering topical agents to the human olfactory epithelium?
Background: Sinonasal diseases are often treated with topical agents administered through various application techniques, but few prior studies have examined their distribution to the olfactory mucosa. To date, the most popularly prescribed preparation of topical therapies is nasal spray; however, recent published studies have highlighted the therapeutic benefits of nasal irrigations.
Explore this issue:December 2013
Study design: Human cadaveric study using eight formaldehyde-preserved cadaveric heads with 15 available nasal sides; image pixel intensity was correlated with staining intensity.
Setting: Department of Otolaryngology–Head and Neck Surgery at Northwestern University, Evanston, Ill.