ENTtoday
  • Home
  • COVID-19
  • Practice Focus
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Departments
    • Issue Archive
    • TRIO Best Practices
      • Allergy
      • Facial Plastic/Reconstructive
      • Head and Neck
      • Laryngology
      • Otology/Neurotology
      • Pediatric
      • Rhinology
      • Sleep Medicine
    • Career Development
    • Case of the Month
    • Everyday Ethics
    • Health Policy
    • Legal Matters
    • Letter From the Editor
    • Medical Education
    • Online Exclusives
    • Practice Management
    • Resident Focus
    • Rx: Wellness
    • Special Reports
    • Tech Talk
    • Viewpoint
    • What’s Your O.R. Playlist?
  • Literature Reviews
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Events
    • Featured Events
    • TRIO Meetings
  • Contact Us
    • About Us
    • Editorial Board
    • Triological Society
    • Advertising Staff
    • Subscribe
  • Advertise
    • Place an Ad
    • Classifieds
    • Rate Card
  • Search

New Approaches to Vascular Anomalies On the Horizon

by Heather Lindsey • June 1, 2009

  • Tweet
  • Email
Print-Friendly Version

OK-432 also appears to be safe. We’ve done dozens and dozens of procedures with OK-432 and never had a complication due to its use, explained Dr. Kerschner.

You Might Also Like

  • Multidisciplinary Treatment Needed for Vascular Anomalies
  • Propranolol Reduces Size and Blood Vessel Density of Infantile Hemangiomas
  • SM12: Hemangiomas in Infants Require Careful Diagnosis
  • An Unofficial First-Line Treatment: Propranolol gains widespread use for infantile hemangiomas
Explore This Issue
June 2009

More than 400 of these procedures have been done in the United States in the past 15 years, added Dr. Bauman.

Elaine C. Siegfried, MDThe French study looks promising, but we don’t have enough data to make propanolol a first-line drug.
-Elaine C. Siegfried, MD

Sclerotherapy may sometimes be used in conjunction with surgery. For example, physicians can use OK-432 in especially large lesions to reduce their size, making surgical resection easier, noted Dr. Kerschner.

Additionally, using sclerotherapy to treat especially large LMs that partially obstruct the airway may make borderline airway obstruction worse, and tracheotomy may be temporarily necessary, noted Dr. Smith.

In general, OK-432 appears to be more effective in achieving resolution of macrocystic LMs than other sclerotherapy agents, said Dr. Kerschner.

Most studies of doxycycline for treatment of LMs have included small numbers of patients and are retrospective, noted Dr. Smith. What would be really interesting is to organize a multi-institutional sclerotherapy study, with half the patients receiving OK-432 and half receiving doxycycline, he said, adding that the two drugs probably work differently. Whereas OK-432 is an immunostimulant that causes the body to attack the inner lining of the LM, the mechanism of doxcycline is poorly understood, and it may act more as a direct irritant, he said.

One advantage of doxycycline is that it is easier to obtain than OK-432, which requires enrollment in a clinical study. Most people aren’t willing to jump through the hoops of pre-study and post-study work, noted Dr. Smith.

The most recent data from the OK-432 Collaborative Study Group (Laryngoscope 2009;119:107-15) concluded that OK-432 immunotherapy is an effective, safe, and simple treatment option for the management of macrocystic cervicofacial lymphatic malformations.

The group conducted a prospective, randomized, multi-institutional, phase II clinical trial at 27 U.S. academic medical centers between January 1998 and November 2004. One hundred seventeen patients were randomized into immediate or delayed treatment groups, and 34 patients were assigned to an open-label group.

Treatment consisted of up to four intralesional OK-432 injections (0.2 mg per injection) delivered at eight-week intervals. Some children would respond well to just a single injection, especially for macrocystic lesions comprised of a single large cyst like a water balloon under the skin, said Dr. Smith, who was one of the study authors.

Pages: 1 2 3 4 5 6 7 | Single Page

Filed Under: Everyday Ethics, Head and Neck, Pediatric Tagged With: infantile hemangiomas, lymphatic malformations (LM), pediatric, tumorIssue: June 2009

You Might Also Like:

  • Multidisciplinary Treatment Needed for Vascular Anomalies
  • Propranolol Reduces Size and Blood Vessel Density of Infantile Hemangiomas
  • SM12: Hemangiomas in Infants Require Careful Diagnosis
  • An Unofficial First-Line Treatment: Propranolol gains widespread use for infantile hemangiomas

The Triological SocietyENTtoday is a publication of The Triological Society.

The Laryngoscope
Ensure you have all the latest research at your fingertips; Subscribe to The Laryngoscope today!

Laryngoscope Investigative Otolaryngology
Open access journal in otolaryngology – head and neck surgery is currently accepting submissions.

Classifieds

View the classified ads »

TRIO Best Practices

View the TRIO Best Practices »

Top Articles for Residents

  • Do Training Programs Give Otolaryngology Residents the Necessary Tools to Do Productive Research?
  • Why More MDs, Medical Residents Are Choosing to Pursue Additional Academic Degrees
  • What Physicians Need to Know about Investing Before Hiring a Financial Advisor
  • Tips to Help You Regain Your Sense of Self
  • Should USMLE Step 1 Change from Numeric Score to Pass/Fail?
  • Popular this Week
  • Most Popular
  • Most Recent
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Experts Delve into Treatment Options for Laryngopharyngeal Reflux
    • Non-Acidic Reflux Explains Lack of Response to H2 Blockers and PPIs
    • Vertigo in the Elderly: What Does It Mean?
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Vertigo in the Elderly: What Does It Mean?
    • New Developments in the Management of Eustachian Tube Dysfunction
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Eustachian Tuboplasty: A Potential New Option for Chronic Tube Dysfunction and Patulous Disease
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Why Virtual Grand Rounds May Be Here to Stay
    • Otolaryngologist Leverages His Love of Pinball into Second Business
    • These New Imaging Advances May Help to Protect Parathyroids
    • Is the Training and Cost of a Fellowship Worth It? Here’s What Otolaryngologists Say
    • Which Otologic Procedures Poses the Greatest Risk of Aerosol Generation?

Polls

Have you used 3D-printed materials in your otolaryngology practice?

View Results

Loading ... Loading ...
  • Polls Archive
  • Home
  • Contact Us
  • Advertise
  • Privacy Policy
  • Terms of Use

Visit: The Triological Society • The Laryngoscope • Laryngoscope Investigative Otolaryngology

Wiley
© 2021 The Triological Society. All Rights Reserved.
ISSN 1559-4939

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.